CLINICAL TRIALS AND OBSERVATIONS Autologous hematopoietic stem cell transplantation in chronic lymphocytic leukemia: results of European intergroup randomized trial comparing autografting versus observation
نویسندگان
چکیده
1Edouard Herriot Hospital, Lyon, France; 2University of Heidelberg, Heidelberg, Germany; 3Victor Dupouy Hospital, Argenteuil, France; 4EBMT Department of Medical Statistics, Leiden, The Netherlands; 5Clinical Trial Service Unit, Oxford, United Kingdom; 6Pitié Salpetrière Hospital, Paris, France; 7Centre hospitalier d’Annecy, Annecy, France; 8Royal Marsden Hospital, London, United Kingdom; 9University Hospital, Basel, Switzerland; 10Johannes-Gutenberg University, Mainz, Germany; 11Institute of Cancer Research, Sutton, United Kingdom; 12University of Cologne, Cologne, Germany; 13Radboud University, Nijmegen, The Netherlands; 14University of Leipzig, Leipzig, Germany; 15CHU de Caen, Caen, France; and 16Birmingham Heartlands Hospital, Birmingham, United Kingdom
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network
Mantle-cell lymphoma (MCL) is characterized by poor prognosis with a median survival of only 3 to 4 years. To improve clinical outcome, the European MCL Network initiated a randomized trial comparing consolidation with myeloablative radiochemotherapy followed by autologous stem cell transplantation (ASCT) to interferon maintenance (IFN ) in first remission. Patients 65 years of age or younger w...
متن کاملCLINICAL TRIALS AND OBSERVATIONS A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation
Donor lymphocyte infusions (DLIs) induce potent graft versus tumor (GVT) effects for relapsed chronic myelogenous leukemia (CML) after allogeneic stem cell transplantation (SCT) but are disappointing for other diseases. Disease resistance can occur if donor T cells are not appropriately activated in vivo. Ex vivo T-cell activation might overcome diseaseinduced anergy and augment GVT activity. W...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Autologous stem cell transplantation as a first-line treatment strategy for chronic lymphocytic leukemia: a multicenter, randomized, controlled trial from the SFGM-TC and GFLLC
Laurent Sutton,1 Sylvie Chevret,2 Olivier Tournilhac,3 Marine Diviné,4 Véronique Leblond,5 Bernadette Corront,6 Stéphane Leprêtre,7 Houchingue Eghbali,8 Eric Van Den Neste,9 Mauricette Michallet,10 Frédéric Maloisel,11 Krimo Bouabdallah,12 Didier Decaudin,13 Christian Berthou,14 Pauline Brice,15 Hugo Gonzalez,16 Elise Chapiro,17 Isabelle Radford-Weiss,18 Nathalie Leporrier,19 Karim Maloum,17 Fl...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic hematopoietic stem cell transplantation using HLA-identical sibling donors in myelodysplastic syndromes
Rodrigo Martino, Simona Iacobelli, Ronald Brand, Thekla Jansen, Anja van Biezen, Jürgen Finke, Andrea Bacigalupo, Dietrich Beelen, Jossy Reiffers, Agnes Devergie, Emilie Alessandrino, Ghulam J. Mufti, Renée Barge, Jorge Sierra, Tapani Ruutu, Marc Boogaerts, Michele Falda, Jean-Pierre Jouet, Dieter Niederwieser, and Theo de Witte, for the Myelodysplastic Syndrome subcommittee of the Chronic Leuk...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Nonmyeloablative allogeneic stem cell transplantation for the treatment of chronic myeloid leukemia in first chronic phase
Reduced-intensity or nonmyeloablative stem cell transplantation (NST) is designed to induce host-versus-graft tolerance by engraftment of donor stem cells. The rationale behind NST is to induce optimal graft-versus-leukemia (GVL) effects for elimination of all malignant cells by donor alloreactive immunocompetent cells as an alternative to standard highdose myeloablative chemoradiotherapy. NST ...
متن کامل